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Top drugs affected by grapefruit: All

Rank Topic Wikipedia views
Oct 21 2010
1 Oxycodone (Oxycodone is metabolized by the cytochrome P450 system, specifically CYP3A4, of which the bergamottin flavonoid is a strong inhibitor) 17245
2 Codeine and Tramadol. </ref> It reduces the amount of codeine converted by CYP3A4 into norcodeine thus increasing the amount metabolised into morphine. Morphine itself, however, is not affected by grapefruit juice, as it is not metabolised by the cytochrome P450 system. 9653
3 Sertraline {{cite journal 8907
4 Zolpidem (Ambien) Increased effect. https://www.health.harvard.edu/fhg/updates/update0206d.shtml</ref> 7863
5 Trazodone (Desyrel) Reports have indicated users experiencing little to no effect. 7258
6 Methadone Inhibits the metabolism of methadone and raises serum levels. 6815
7 Omeprazole 5986
8 Quetiapine (Seroquel, Ketipinor) 5694
9 Buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4 4928
10 Statins such as atorvastatin, lovastatin, and simvastatin with the exception of Pravastatin which is unaffected. </ref> 4448
11 Psilocybin 3162
12 Carbamazepine (Tegretol) Grapefruit or grapefruit juice slows the breakdown of this drug, increasing the level of it in blood 2790
13 Fluvoxamine (Luvox, Faverin, Fevarin and Dumyrox) </ref> 1785
14 Cisapride (which treats GERD) 467
15 Slow release versions of drugs are affected by grapefruit, causing the entire dosage to be metabolized at once. 443
16 Ritonavir inhibits CYP3A4 preventing the metabolism of protease inhibitors {{cite web 417
17 Marijuana Oral ingestion 82
18 The benzodiazepines triazolam, midazolam, alprazolam and quazepam < 5
19 verapamil (Calan SR, Covera HS, Isoptin SR, Verelan) < 5
20 Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal stromal tumors. < 5
21 Anthelmintics (Used for treating certain parasitic infections, includes Praziquantel Albendazole Mebendazole) < 5
22 Dihydropyridines including felodipine (Plendil), nicardipine (Cardene), difedipine, nisoldipine (Sular), nitrendipine (Bayotensin) < 5
23 repaglinide (Prandin) < 5
24 losartan (Cozaar) < 5
25 Cyclosporine. Blood levels of cyclosporine are increased if taken with grapefruit juice. A plausible mechanism involves the combined inhibition of enteric CYP3A4 and P-glycoprotein, which potentially leads to serious adverse events (eg, nephrotoxicity).Blood levels of Prograf [link] can also be equally affected for the same reason as it does with Cyclosporine [link] < 5
26 buspirone < 5

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